Journal
MOLECULAR AND CELLULAR NEUROSCIENCE
Volume 39, Issue 2, Pages 193-201Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.mcn.2008.06.009
Keywords
Learning; Consolidation; Histone H3 acerylation; Sodium butyrate; Trichostatin A; Histone deacetylase; Gene expression; SAMP-8 mice; Kainic acid; Aging
Categories
Funding
- AECI
- Junta de Andalucia [CVI-122, CTS-168]
- DGICYT [BFU2005-01024]
Ask authors/readers for more resources
Histone deacetylases (HDAC) are enzymes that maintain chromatin in a condensate state, related with absence of transcription. We have studied the role of HDAC on learning and memory processes. Both eyeblink classical conditioning (EBCC) and object recognition memory (ORM) induced an increase in histone H3 acetylation (Ac-H3). Systemic treatment with HDAC inhibitors improved cognitive processes in EBCC and in ORM tests. Immunohistochemistry and gene expression analyses indicated that administration of HDAC inhibitors decreased the stimulation threshold for Ac-H3, and gene expression to reach the levels required for learning and memory. Finally, we evaluated the effect of systemic administration of HDAC inhibitors to mice models of neurodegeneration and aging. HDAC inhibitors reversed learning and consolidation deficits in ORM in these models. These results point Out HDAC inhibitors as candidate agents for the palliative treatment of learning and memory impairments in aging and in neurodegenerative disorders. (c) 2008 Published by Elsevier Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available