Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 382, Issue 1, Pages 612-615Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2013.03.023
Keywords
Signal Transducer and Activator of Transcription (STAT); Breast cancer sub-types; ER plus breast cancer; HER2 amplified breast cancer; Triple negative breast cancer
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Funding
- NIH NCI [5P30CA051008]
- WCU (World Class University) program through the National Research Foundation of Korea
- Ministry of Education, Science and Technology [R31-1069]
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This review summarizes information on expression of Signal Transducer and Activator of Transcription (STAT)s 1 , 2, 3, 4, 5a/b and 6 in cancer cells from different human breast cancer sub-types. STAT proteins, especially STATs 1, 3 and 5a/b are expressed in some but not all cancers from all of the different major breast cancer sub-types. However, well-designed studies comparing expression patterns at the protein level in cancer and surrounding stromal cells are still needed to fully examine links with prognosis and therapeutic response. Moreover, it is not yet known if distinct expression patterns of STAT proteins could have dissimilar impacts in different sub-types, especially between the luminal A and B ER+ sub-types and the different TNBC sub-types. Recent data indicating that STAT 5 can be activated secondary to a therapeutic intervention and mediate resistance suggests that expression patterns should not only be examined in pre-treatment but also post-treatment samples from different sub-types. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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