Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 397, Issue 1-2, Pages 42-50Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2014.08.002
Keywords
Food intake; Hormones; Insulin; Obesity; SIRT1
Categories
Funding
- Ministerio de Economia y Competitividad [RYC-2008-02219, BFU2012-35255]
- Xunta de Galicia [EM 2012/039, 2012-CP069]
- Centro de Investigacion Biomedica en Red (CIBER) de Fisiopatologia de la Obesidad y Nutricion (CIBERobn)
- European Community Seventh Framework Programme (FP7) [245009: NeuroFAST, ERC-2011-StG-OBESITY53-281408]
- FEDER
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The mammalian sirtuins (SIRT1-7) are a family of highly conserved nicotine adenine dinucleotide (NAD(+))-dependent deacetylases that act as cellular sensors to detect energy availability. SIRT1 is a multifaceted protein that is involved in a wide variety of cellular processes. SIRT1 is activated in response to caloric restriction, acting on multiple targets in a wide range of tissues. SIRT1 regulates the role of multiple hormones implicated in energy balance, including glucose and lipid metabolism. Here, we review the relevant role of SIRT1 as a mediator of endocrine function of several hormones to modulate energy balance. In addition, we analyze the potential of targeting SIRT1 for the treatment of obesity and type 2 diabetes mellitus. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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