Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 398, Issue 1-2, Pages 78-88Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2014.10.005
Keywords
Corpus luteum; MicroRNA; Cattle; High-throughput sequencing; Maternal recognition of pregnancy
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Funding
- Agriculture and Food Research Initiative Competitive from the USDA National Institute of Food and Agriculture [2012-67015-30212]
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The role of miRNA in tissue biology has added a new level of understanding of gene regulation and function. The corpus luteum (CL) is a transitory endocrine gland; the dynamic nature of the CL makes it a candidate for regulation by miRNA. Rescue of the CL from luteolysis is essential for the maintenance of pregnancy in all eutherian mammals. Using next generation sequencing, we profiled miRNA expression in the bovine CL during maternal recognition of pregnancy. We identified 590 luteal miRNA, of which 544 were known and 46 were novel miRNAs. Fifteen (including 3 novel) miRNAs were differentially expressed between CL of pregnant vs. cyclic animals. Target analysis of the differentially expressed miRNA resulted in genes involved in regulating apoptosis and immune response, providing evidence that miRNAs regulate the intracellular pathways that lead to either luteal regression or survival. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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