Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 385, Issue 1-2, Pages 88-96Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2013.10.003
Keywords
Golgi apparatus; Microtubule-organizing center (MTOC); Cellular polarity; Pituitary; Gonadotrope; GnRH signaling
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Funding
- Grants-in-Aid for Scientific Research [24890012] Funding Source: KAKEN
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In contrast to the widely accepted images of the Golgi apparatus as a cup-like shape, the Golgi in pituitary gonadotropes is organized as a spherical shape in which the outer and inner faces are cis- and trans-Golgi elements, respectively. At the center of the spherical Golgi, a pair of centrioles is situated as a microtubule-organizing center from which radiating microtubules isotropically extend toward the cell periphery. This review focuses on the significance of the characteristic organization of the Golgi and microtubule network in gonadotropes, considering the roles of microtubule-dependent membrane transport in the formation and maintenance of the Golgi structure. Because the highly symmetrical organization of the Golgi is possibly perturbed in response to experimental treatments of gonadotropes, monitoring of the Golgi structure in gonadotropes under various experimental conditions will be a novel in vivo approach to elucidate the biogenesis of the Golgi apparatus. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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