Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 388, Issue 1-2, Pages 10-19Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2014.03.001
Keywords
Beta cell; Pancreas; Egr-1; Insulin; Pdx-1; Transcription
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Funding
- University of Saarland
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Egr-1 and the related zinc finger transcription factors Egr-2, Egr-3, and Egr-4 are stimulated by many extracellular signaling molecules and represent a convergence point for intracellular signaling cascades. Egr-1 expression is induced in insulinoma cells and pancreatic beta-cells following stimulation with either glucose, or pregnenolone sulfate. Moreover, stithulation of G alpha q and G alpha s-coupled receptors enhances EGR-1 gene transcription. Functional studies revealed that Egr transcription factors control insulin biosynthesis via regulation of Pdx-1 expression. Glucose homeostasis and pancreatic islet size are regulated by Egr transcription factors, indicating that these proteins control central physiological parameters regulated by pancreatic beta-cells. In addition, Egr-1 is an integral part of the insulin receptor signaling cascade in insulin-responsive tissues and influences insulin resistance. (c) 2014 Elsevier Ireland Ltd. All rights reserved.
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