Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 383, Issue 1-2, Pages 137-146Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2013.12.005
Keywords
Human adipocyte; TRPM8; UCP1; Mitochondria; Menthol
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Mammals possess two types of adipose tissue, white (WAT) and brown (BAT). The uncoupling protein I (UCP1) is a hallmark of BAT, being the pivotal player for cold-induced thermogenesis. WAT can acquire BAT characteristics with up-regulation of UCP1 after cold exposure or adrenergic stimulation. In the present study we demonstrated that human white adipocytes express the cold-sensing receptor TRPM8 which activation by menthol and icilin induced a rise in [Ca2+](i) and UCP1 expression, increased mitochondrial membrane potential, glucose uptake and heat production. The induction of brown-like phenotype in human white adipocytes after TRPM8 activation was supported by ultrastructural morphological changes of mitochondria] morphology and of their intracellular localization, with no modifications of the genes regulating mitochondrial biogenesis. In conclusion human white adipocytes express the cold receptor TRPM8 which activation induces their browning supporting a possible role of this receptor in the control of adipose tissue metabolism and body energy balance. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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