Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 380, Issue 1-2, Pages 41-54Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2012.12.014
Keywords
Glucocorticoids; Glucocorticoid receptor; Transactivation; Transrepression; Cross-talk; Transcription factor
Categories
Funding
- strategic basic research grant from IWT-Vlaanderen
- NOI (nieuwe onderzoeksinitiatieven) research grant from the University of Antwerp
- Methusalem grant of the University of Gent
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The activity of the glucocorticoid receptor (GR), a nuclear receptor transcription factor belonging to subclass 3C of the steroid/thyroid hormone receptor superfamily, is typically triggered by glucocorticoid hormones. Apart from driving gene transcription via binding onto glucocorticoid response elements in regulatory regions of particular target genes, GR can also inhibit gene expression via transrepression, a mechanism largely based on protein:protein interactions. Hereby GR can influence the activity of other transcription factors, without contacting DNA itself. GR is known to inhibit the activity of a growing list of immune-regulating transcription factors. Hence, GCs still rule the clinic for treatments of inflammatory disorders, notwithstanding concomitant deleterious side effects. Although patience is a virtue when it comes to deciphering the many mechanisms GR uses to influence various signaling pathways, the current review is testimony of the fact that groundbreaking mechanistic work has been accumulating over the past years and steadily continues to grow. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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