Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 366, Issue 2, Pages 224-234Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2012.02.004
Keywords
Inflammation; Obesity; Diabetes; Cardiovascular disease; Metabolism; Cytokine
Categories
Funding
- Canadian Diabetes Association (CDA)
- Heart and Stroke Foundation of Canada (HSF)
- Canadian Institutes of Health Research (CIHR)
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Obesity leads to insulin resistance and atherosclerosis, which precede Type 2 diabetes and cardiovascular disease. Immunometabolism addresses how metabolic and inflammatory pathways converge to maintain health and a contemporary problem is determining how obesity-induced inflammation precipitates chronic diseases such as insulin resistance and atherosclerosis. AMP-activated protein kinase (AMPK) is an important serine/threonine kinase well known for regulating metabolic processes and maintaining energy homeostasis. However, both metabolic and immunological AMPK-mediated effects play a role in disease. Pro-inflammatory mediators suppress AMPK activity and hinder lipid oxidation. In addition, AMPK activation curbs inflammation by directly inhibiting pro-inflammatory signaling pathways and limiting the build-up of specific lipid intermediates that elicit immune responses. In the context of obesity and chronic disease, these reciprocal responses involve both immune and metabolic cells. Therefore, the immunometabolism of AMPK-mediated processes and therapeutics should be considered in atherosclerosis and insulin resistance. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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