Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 348, Issue 2, Pages 361-372Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2011.09.026
Keywords
Estrogen receptor; Estrogen related receptor; Fertility; Cancer
Categories
Funding
- Medical Research Council [G1100356, G1002033] Funding Source: Medline
- MRC [G1100356, G1002033] Funding Source: UKRI
- Medical Research Council [G1100356, G1002033] Funding Source: researchfish
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Estrogens play a fundamental role in the development and normal physiological function of multiple tissue systems and have been implicated in the ontogeny of cancers. The biological effects of estrogens are classically mediated via interaction with cognate nuclear receptors. The relative expression of ER subtypes/variants varies between cells within different tissues and this alters the response to natural and synthetic ligands. This review focuses on the role of estrogen and estrogen related receptors in reproductive tissues. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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