Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 354, Issue 1-2, Pages 54-59Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2011.11.013
Keywords
Developmental programming; Health and productivity; Placenta; Epigenetics; Therapeutic/management strategies
Categories
Funding
- Agriculture and Food Research Initiative of the US National Institute of Food and Agriculture
- National Heart, Lung and Blood Institute, and National Institute of Child Health and Human Development of the US National Institutes of Health
- North Dakota Agricultural Experiment Station
- US National Science Foundation
Ask authors/readers for more resources
The concept that developmental insults (for example, poor pre- or postnatal nutrition) can have long-term consequences on health and well-being of the offspring has been termed developmental programming. In livestock, developmental programming affects production traits, including growth, body composition, and reproduction. Although low birth weight was used as a proxy for compromised fetal development in the initial epidemiological studies, based on controlled studies using livestock and other animal models in the last two decades we now know that developmental programming can occur independently of any effects on birth weight. Studies in humans, rodents, and livestock also have confirmed the critical role of the placenta in developmental programming. In addition, the central role of epigenetic regulation in developmental programming has been confirmed. Lastly, relatively simple therapeutic/management strategies designed to 'rescue' placental development and function are being developed to minimize the effects of developmental programming on health and productivity of humans, livestock, and other mammals. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available