Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 364, Issue 1-2, Pages 46-53Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2012.08.008
Keywords
Incretin receptors; GLP-2; Crohn's disease; Short bowel syndrome; Gastrointestinal stromal tumor
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Funding
- Krebsliga Schweiz [OCS 02349-02-2009]
- Desiree and Niels Yde Foundation
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Peptide hormones of the glucagon-like peptide (GLP) family play an increasing clinical role, as reported for GLP-1 in diabetes therapy and insulinoma diagnostics. GLP-2, despite its known trophic and anti-inflammatory intestinal actions translated into preliminary clinical studies using the GLP-2 analogue teduglutide for treatment of short bowel syndrome and Crohn's disease, remains poorly characterized in terms of expression of its receptor in tissues of interest. Therefore, the GLP-2 receptor expression was assessed in 237 tumor and 148 non-neoplastic tissue samples with in vitro receptor autoradiography. A GLP-2 receptor expression was present in 68% of gastrointestinal stromal tumors (GIST). Furthermore, GLP-2 receptors were identified in the intestinal myenteric plexus, with significant up-regulation in active Crohn's disease. The GLP-2 receptors in GIST may be used for clinical applications like in vivo targeting with radiolabelled GLP-2 analogues for imaging and therapy. Moreover, the over-expressed GLP-2 receptor in the myenteric plexus may represent the morphological correlate of the clinical target of teduglutide in Crohn's disease. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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