Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 352, Issue 1-2, Pages 34-45Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2011.06.033
Keywords
Androgen receptor; Cell cycle; Prostate cancer
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Funding
- NCI NIH HHS [R01 CA099996] Funding Source: Medline
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Prostate cancer cells are exquisitely dependent on androgen receptor (AR) activity for proliferation and survival. As these functions are critical targets of therapeutic intervention for human disease, it is imperative to delineate the mechanisms by which AR engages the cell cycle engine. More than a decade of research has revealed that elegant intercommunication between AR and the cell cycle machinery governs receptor-dependent cellular proliferation, and that perturbations in this process occur frequently in human disease. Here, AR-cell cycle interplay and associated cancer relevance will be reviewed. (C) 2011 Published by Elsevier Ireland Ltd.
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