Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 353, Issue 1-2, Pages 68-74Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2011.10.023
Keywords
PtdIns(4,5)P-2; PIP2; TRP channel; TRPM8; Temperature sensation
Categories
Funding
- National Institutes of Health [NS055159, GM093290]
- UMDNJ Foundation
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Transient Receptor Potential Melastatin 8 (TRPM8) is a Ca2+ permeable non-selective cation channel directly activated by cold temperatures and chemical agonists such as menthol. It is a well established sensor of environmental cold temperatures, found in peripheral sensory neurons, where its activation evokes depolarization and action potentials. The activity of TRPM8 is regulated by a number of cellular signaling pathways, most notably by phosphoinositides and the activation of phospholipase C. This review will summarize current knowledge on the physiological and pathophysiological roles of TRPM8 and its regulation by various intracellular messenger molecules and signaling pathways. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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