Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 361, Issue 1-2, Pages 172-178Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2012.04.005
Keywords
Obesity; Insulin-like growth factor-1; Insulin-like growth factor-1 receptor; Insulin-like growth factor binding protein; Monocytes; Adipose tissue
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Funding
- IGA [10024-4]
- [RVO-VFN64165/2012]
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We explored serum concentrations and mRNA expression of insulin-like-growth factor-1 (IGF-1) axis components in subcutaneous adipose tissue (SCAT) and peripheral monocytes (PM) of 18 healthy females, 11 obese non-diabetic females (OB) and 13 obese women with type 2 diabetes (T2DM) examined at baseline and after very-low-calorie diet (VLCD). T2DM women had decreased expression of IGF-1, IGF-1 receptor (IGF-1R), IGFBP-2 (IGF binding protein-2) and IGFBP-3 in SCAT and increased expression of IGF-1R in PM compared to control group. IGF-1R and IGFBP-3 mRNA expression in SCAT of OB was comparable to control group. In T2DM women VLCD increased serum levels and SCAT expression of IGFBP-2 and PM expression of IGFBP-3. We conclude that decreased IGF-1, IGF-1R and IGFBP-3 expression in SCAT and increased IGF-1R expression in PM of T2DM subjects might contribute to changes of fat differentiation capacity and to regulation of subclinical inflammation by PM, respectively. Increased SCAT and circulating IGFBP-2 and IGFBP-3 in PM might participate in metabolic improvements after VLCD. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
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