Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 362, Issue 1-2, Pages 194-201Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2012.06.010
Keywords
Vascular smooth muscle cells; Oleic acid; Palmitic acid; NF-kappa B; Inflammation; Vascular dysfunction
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Funding
- MinisteriumfurWissenschaft und Forschung des Landes Nordrhein-Westfalen
- Bundesministerium far Gesundheit
- Deutsche Forschungsgemeinschaft [SE 1922/2-1]
- Commission of the European Communities [HEALTH-F2-2008-201100]
- EU COST Action [BM0602]
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It is widely accepted that obesity is a major risk factor for the development of atherosclerosis. In this context, adipose tissue produces a variety of adipokines and releases free fatty acids, contributing to a chronic-low grade inflammation state implicated in vascular complications. In this study, we investigated the role of adipokines, oleic acid (OA), palmitic acid (PA), and the combinations on activation of NF-kappa B target genes in human vascular smooth muscle cells (SMC) to assess the hypothesis of synergistic interactions between these molecules. Adipocyte-conditioned medium (CM), generated from human adipocytes, in combination with low concentrations of OA, but not PA, induces SMC proliferation and activation of the transcription factor NF-kappa B in a synergistic way. Combined treatment of CM and OA further regulates a set of downstream NF-kappa B target genes including angiopoietin-1, activin A, and MMP-1, all critically involved in SMC dysfunction. This suggests that the lipotoxic potential of fatty acids is substantially enhanced by the presence of adipocyte-derived factors. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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