Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 340, Issue 1, Pages 88-96Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2011.02.013
Keywords
Ghrelin; Sleep; Depression; Memory; Mental health
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Funding
- Deutsche Forschungsgemeinschaft [DFG Ste 486/5-3, DFG Ste 486/5-4, DFG Ste 486/5-5]
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Ghrelin acts as a neuropeptide. It participates in sleep-wake regulation. After systemic ghrelin treatment nonREM sleep is promoted in male humans and mice. This effect is influenced by gender, time of administration and depression. Ghrelin does not modulate sleep in healthy women and during the early morning in male subjects. In depressed women REM sleep is diminished after ghrelin. In elderly men and depressed men sleep promotion by ghrelin was preserved. In rats after central ghrelin feeding and wakefulness increased. The nocturnal secretion pattern of cortisol, GH, LH, FSH and hypothalamo-pituitary-thyroid hormones are influenced by ghrelin. Furthermore ghrelin appears to be related to memory and to be involved in the pathophysiology of CNS disorders, particularly depression. (c) 2011 Elsevier Ireland Ltd. All rights reserved.
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