Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 331, Issue 2, Pages 205-214Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2010.07.010
Keywords
GPCR; Trafficking; Signaling; Endocytosis; Recycling; Degradation
Categories
Funding
- Wellcome Trust
- Genesis Research Trust
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G-protein-coupled receptors (GPCRs) are a superfamily of cell surface signaling proteins that act as central molecular activators and integrators in all endocrine systems. Membrane trafficking of GPCRs is a fundamental process in shaping extensive signaling networks activated by these receptors. Mounting evidence has identified an increasingly complex network of pathways and protein interactions that a GPCR can traverse and associate with, indicating a multi-level system of regulation. This review will discuss the recent developments in how GPCRs are trafficked to the cell surface as newly synthesized receptors, their recruitment to the clathrin-mediated pathway for endocytosis, and their sorting to subsequent divergent post-endocytic fates, focusing primarily on hormone-activated GPCRs. Current models depicting the classic roles membrane trafficking plays in GPCR signaling have evolved to a highly regulated and complex system than previously appreciated. These developments impart key mechanistic information on how spatial and temporal aspects of GPCR signaling may be integrated and could provide pathway-specific targets to be exploited for therapeutic intervention. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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