Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 335, Issue 1, Pages 42-51Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2010.08.006
Keywords
Menstruation; Implantation; Fibroids; Endometriosis; Menorrhagia; Prostaglandins; Hypoxia
Categories
Funding
- MRC [G0600048, U.1276.00.004.00002.01]
- MRC [G0600048, G1002033, MC_U127684438] Funding Source: UKRI
- Medical Research Council [MC_U127684438, G1002033, G0600048] Funding Source: researchfish
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Complex interactions between the endocrine and immune systems govern the key endometrial events of implantation and menstruation. In contrast to other tissue sites, cyclical endometrial inflammation is physiological. However, dysregulation of this inflammatory response can lead to endometrial disorders. This review examines the inflammatory processes occurring in the normal endometrium during menstruation and implantation, highlighting recent advances in our understanding and gaps in current knowledge. Subsequently, the role of inflammatory pathways in the pathology of various common endometrial conditions is discussed, including heavy menstrual bleeding, dysmenorrhoea (painful periods), uterine fibroids, endometriosis and recurrent miscarriage. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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