Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 344, Issue 1-2, Pages 35-40Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2011.06.015
Keywords
Skin; Epidermis; Aromatase; Estrogen receptors; Age; Gender
Categories
Ask authors/readers for more resources
Local estrogen metabolism and its sensitivities in the skin have been also suggested to contribute to skin homeostasis in addition to age- and/or gender-dependent circulating estrogen, even though their local mechanisms have been largely unknown. To characterize their potential correlations, age- and gender-dependencies were evaluated focusing on 5 pivotal estrogen-metabolizing enzymes including aromatase, estrogen sulfotransferase, steroid sulfatase, and 17 beta-hydroxysteroid dehydrogenases and estrogen receptors (ER alpha and ER beta) using immunohistochemistry of 100 human skin specimens. When their epidermal expression levels were compared among 7 age groups, ranging from the teens to the seventies, the highest expression in the teens group and the lowest expression in the seventies group were found in the expression of aromatase and ER beta, respectively, while no significant differences between the male and the female groups were found in the immunoreactivities of our interested proteins. Our results suggest that age-related differences in aromatase and ER beta expressions impact epidermal homeostasis. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available