Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 338, Issue 1-2, Pages 10-17Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2011.02.016
Keywords
Type 2 diabetes; Skeletal muscle; Inflammation; Microarrays; Gene expression
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Funding
- National Institute of General Medical Sciences, NIH, Bethesda, MD [GM 24211]
- UB-Pfizer Strategic Alliance
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The Goto-Kakizaki (GK) rat, a polygenic non-obese model of type 2 diabetes, is a useful surrogate for study of diabetes-related changes independent of obesity. GK rats and appropriate controls were killed at 4, 8, 12, 16 and 20 weeks post-weaning and differential muscle gene expression along with body and muscle weights, plasma hormones and lipids, and blood cell measurements were carried out. Gene expression analysis identified 204 genes showing 2-fold or greater differences between GK and controls in at least 3 ages. Array results suggested increased oxidative capacity in GK muscles, as well as differential gene expression related to insulin resistance, which was also indicated by HOMA-IR measurements. In addition, potential new biomarkers in muscle gene expression were identified that could be either a cause or consequence of T2DM. Furthermore, we demonstrate here the presence of chronic inflammation evident both systemically and in the musculature, despite the absence of obesity. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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