Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 316, Issue 1, Pages 79-85Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2009.08.009
Keywords
Sex hormone-binding globulin; SHBG; cAMP; Second messenger; Breast; Prostate
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Sex hormone-binding globulin (SHBG) was initially described as a plasma protein synthesized in, and secreted by, the liver. It was discovered by its ability to bind certain androgens and estrogens and, for many years, was believed to serve as a transporter/reservoir for the steroids which it bound. Subsequently, it became clear that the cell membranes of selected tissues contained a receptor for SHBG (R-SHBG). This review deals with what is known of that receptor - its anatomy, physiology and biochemistry. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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