Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 314, Issue 2, Pages 192-203Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2009.09.003
Keywords
Luteinizing hormone; Follicle-stimulating hormone; Gonadotropin-releasing hormone; Pituitary; Reproduction
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Funding
- NICHD NIH HHS [R03 HD054595, R01 HD057549-02, R01 HD057549-01A1, R03 HD054595-01A2, F32 HD041301, U54 HD012303-29, T32 HD007203, R01 HD020377-26, U54 HD012303, R01 HD057549, P50 HD012303, R01 HD020377, U54 HD012303-296872, R21 HD058752, F32 HD41301, R21 HD058752-01A1, R03 HD054595-02, T32 HD007203-27] Funding Source: Medline
- NIDDK NIH HHS [R01 DK044838-20, K01 DK080467, R01 DK044838, F32 DK065437] Funding Source: Medline
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The precise interplay of hormonal influences that governs gonadotropin hormone production by the pituitary includes endocrine, paracrine and autocrine actions of hypothalamic gonadotropin-releasing hormone (GnRH), activin and steroids. However, most studies of hormonal regulation of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in the pituitary gonadotrope have been limited to analyses of the isolated actions of individual hormones. LH beta and FSH beta subunits have distinct patterns of expression during the menstrual/estrous cycle as a result of the integration of activin, GnRH, and steroid hormone action. In this review, we focus on studies that delineate the interplay among these hormones in the regulation of LH beta and FSH beta gene expression in gonadotrope cells and discuss how signaling cross-talk contributes to differential expression. We also discuss how recent technological advances will help identify additional factors involved in the differential hormonal regulation of LH and FSH. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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