Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 323, Issue 1, Pages 76-93Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2009.12.013
Keywords
Germ cell; Gonad; Specification; Migration; Proliferation; Epigenetics; Differentiation; Meiosis; Mitotic arrest
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Funding
- Australian Research Council (ARC)
- National Health and Medical Research Council of Australia
- Australian Postgraduate Award
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Primordial germ cells (PGCs) are embryonic progenitors for the gametes. In the gastrulating mouse embryo, a small group of cells begin expressing a unique set of genes and so commit to the germline. Over the next 3-5 days, these PGCs migrate anteriorly and increase rapidly in number via mitotic division before colonizing the newly formed gonads. PGCs then express a different set of unique genes, their inherited epigenetic imprint is erased and an individual methylation imprint is established, and for female PGCs, the silent X chromosome is reactivated. At this point, germ cells (GCs) commit to either a female or male sexual lineage, denoted by meiosis entry and mitotic arrest, respectively. This developmental program is determined by cues emanating from the somatic environment. Crown Copyright (C) 2009 Published by Elsevier Ireland Ltd. All rights reserved.
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