Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 321, Issue 1, Pages 67-76Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2010.02.022
Keywords
Oncocytic tumors; mtDNA mutations; Follicular tumors; Papillary tumors
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Funding
- Associazione Italiana Ricerca sul Cancro (AIRC) [1145, 8810]
- European Commission [SH-2005-2.2.0-2]
- Ricerca Fondamentale Orientata, MURST
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Thyroid oncocytic neoplasms are tumors composed of cells characterized by an aberrant increase of mitochondrial mass. They represent a subset of thyroid tumors whose classification and clinical features has been a matter of controversy for clinicians and pathologists alike. The prevalence of oncocytic tumors in the thyroid gland, the relevance of the issues debated, and the obvious cellular derangement of oncocytic cells, namely a complete deregulation of the mitochondrial mass and metabolism, have spurred many investigators to study the molecular mechanism underlying the genesis of this peculiar cancer phenotype. Their findings, which are unraveling the tumor pathobiology, are the subject of the present review. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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