Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 321, Issue 1, Pages 36-43Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2009.09.013
Keywords
Thyroid cancer; RET/PTC; Nuclear architecture; DNA repair
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Funding
- NCI NIH HHS [R01 CA088041, R01 CA088041-08] Funding Source: Medline
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Thyroid cancer, and its most common type, papillary carcinoma, frequently have chromosomal rearrangements and therefore represent a good model for the understanding of mechanisms of chromosomal rearrangements in solid tumors. Several types of rearrangement known to occur in thyroid cancer, including RET/PTC, NTRK1 and BR4F/AKAP9, are more common in radiation-associated thyroid tumors and RET/PTC can be induced experimentally by exposing human thyroid cells to ionizing radiation. In this review, the molecular mechanisms of generation of RET/PTC and other chromosomal rearrangements are discussed, with the emphasis on the role of nuclear architecture and interphase gene proximity in the generation of intrachromosomal rearrangements in thyroid cells. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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