Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 308, Issue 1-2, Pages 9-16Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2009.03.009
Keywords
Endothelial cell; Estradiol; Estrogen receptor; Genomic signaling; GPER; GPR30; Non-genomic signaling; Plasma membrane; Vascular smooth muscle cell
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Funding
- Swiss National Science Foundation [3200-108258/1, K-33KO-122504/1]
- NIH [CA116662, CA118743]
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Estrogens exert rapid, non-genomic effects, which are mediated by plasma membrane-associated estrogen receptors (mER) mER alpha and mER beta, and the intracellular transmembrane G protein-coupled estrogen receptor (GPER). Membrane-initiated responses contribute to transcriptional activation, resulting in a complex interplay of nuclear and extra-nuclear mechanisms that mediate the acute physiological responses to estrogens. Non-genomic estrogen signaling also activates a variety of intracellular estrogen signaling pathways that regulate vascular function and cell growth involving rapid but also long-term effects. This review discusses recent advances in understanding of the mechanisms of non-genomic estrogen receptor signaling in the vascular wall. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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