Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 299, Issue 1, Pages 39-50Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2008.07.005
Keywords
Aging; Reproduction; Drosophila; Insulin/IGF-like signaling; Ecdysone; Juvenile hormone
Categories
Funding
- United Kingdom Biotechnology
- Biological Sciences Research Council
- The Wellcome Trust
- Biotechnology and Biological Sciences Research Council [BB/C51705X/1] Funding Source: researchfish
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Hormonal signals can modulate lifespan and reproductive capacity across the animal kingdom. The use of model organisms such as worms, flies and mice has been fundamentally important for aging research in the discovery of genetic alterations that can extend healthy lifespan. The effects of mutations in the insulin and insulin-like growth factor-like signaling (IIS) pathways are evolutionarily conserved in that they can increase lifespan in all three animal models. Additionally, steroids and other lipophilic signaling molecules modulate lifespan in diverse organisms. Here we shall review how major hormonal pathways in the fruit fly Drosophila melanogaster interact to influence reproductive capacity and aging. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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