Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 294, Issue 1-2, Pages 70-80Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2008.08.017
Keywords
Testis; Ovary; Knockout; TGF-beta 1; TGF-beta 2; TGF-beta 3; Embryonic development
Categories
Funding
- NIH NICHD
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The role transforming growth factor beta (TGFb) isoforms TGFb1, TGFb2 and TGFb3 have in the regulation of embryonic gonadal development was investigated with the use of null-mutant (i.e. knockout) mice for each of the TGFb isoforms. Late embryonic gonadal development was investigated because homozygote TGFb null-mutant mice generally die around birth, with some embryonic loss as well. In the testis, the TGFb1 null-mutant mice had a decrease in the number of germ cells at birth, postnatal day 0 (P0). In the testis, the TGFb2 null-mutant mice had a decrease in the number of seminiferous cords at embryonic day 15 (E15). In the ovary, the TGFb2 null-mutant mice had an increase in the number of germ cells at P0. TGFb isoforms appear to have a role in gonadal development, but interactions between the isoforms is speculated to compensate in the different TGFb isoform null-mutant mice. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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