Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 288, Issue 1-2, Pages 79-85Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2008.03.001
Keywords
human; mouse; pancreas; stem cell; hormone; beta-cell; diabetes
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Funding
- Biotechnology and Biological Sciences Research Council Funding Source: Medline
- Wellcome Trust [074320] Funding Source: Medline
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Understanding how beta-cells maintain themselves in the adult pancreas is important for prioritizing strategies aimed at ameliorating or ideally curing different forms of diabetes. There has been much debate over whether beta-cell proliferation, as a means of self-renewal, predominates over the existence and differentiation of a pancreatic stem cell or progenitor cell population. This article describes the two opposing positions based largely on research in laboratory rodents and its extrapolation to humans. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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