Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 286, Issue 1-2, Pages 63-68Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2007.12.006
Keywords
dimerization; dopamine receptor; G protein-coupled receptor; opioid receptor; somatostatin receptor
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Somatostatin acts through binding and activation of five G protein-coupled receptors (GPCRs) termed somatostatin receptors or ssts (sst1-sst5). These receptors, as many other GPCRs are not just monomers but display a differential tendency to homodimerize, which varies depending on the sst subtype. Moreover, there is evidence that pairs of distinct receptors such as ssst2-sst3 and sst1-sst5 crosstalk by establishing a physical interaction, which results in altered pharmacological or/and functional properties. In addition, ssts can also heterodimerize with other families of GPCRs, as opioid and dopamine receptors, originating heterodimers which properties are different to those of their separated receptors. The present review summarizes the current knowledge on ssts homodimerization, heterodimerization, and interaction with other GPCRs, as well as how interactions affect different aspects of the normal functioning of these receptors. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
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