4.5 Article

Regulated Proteolysis of NOTCH2 and NOTCH3 Receptors by ADAM10 and Presenilins

Related references

Note: Only part of the references are listed.
Letter Dermatology

Epidermal ADAM17 Is Dispensable for Notch Activation

Arjan J. Groot et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2013)

Article Oncology

Molecular Pathways: Context-Dependent Approaches to Notch Targeting as Cancer Therapy

Ann Marie Egloff et al.

CLINICAL CANCER RESEARCH (2012)

Article Multidisciplinary Sciences

Direct observation of proteolytic cleavage at the S2 site upon forced unfolding of the Notch negative regulatory region

Natalie L. Stephenson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy

Shannon M. McAuliffe et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Cell Biology

Notch signaling in human development and disease

Andrea L. Penton et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Cleavage of Notch1 by granzyme B disables its transcriptional activity

Geert van Tetering et al.

BIOCHEMICAL JOURNAL (2011)

Review Medicine, Research & Experimental

Proteolytic Cleavage of Notch: HIT and RUN

G. van Tetering et al.

CURRENT MOLECULAR MEDICINE (2011)

Review Neurosciences

The Many Substrates of Presenilin/gamma-Secretase

Annakaisa Haapasalo et al.

JOURNAL OF ALZHEIMERS DISEASE (2011)

Article Genetics & Heredity

Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss

Michael A. Simpson et al.

NATURE GENETICS (2011)

Article Oncology

E-Cadherin loss associated with EMT promotes radioresistance in human tumor cells

Jan Theys et al.

RADIOTHERAPY AND ONCOLOGY (2011)

Article Biochemistry & Molecular Biology

A Disintegrin and Metalloproteinase 17 (ADAM17) Mediates Inflammation-induced Shedding of Syndecan-1 and-4 by Lung Epithelial Cells

Jessica Pruessmeyer et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Cell Biology

ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site

Sylvain M. Le Gall et al.

JOURNAL OF CELL SCIENCE (2010)

Article Immunology

ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo

David R. Gibb et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2010)

Article Multidisciplinary Sciences

Therapeutic antibody targeting of individual Notch receptors

Yan Wu et al.

NATURE (2010)

Review Biochemistry & Molecular Biology

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

Raphael Kopan et al.

Article Biochemistry & Molecular Biology

Metalloprotease ADAM10 Is Required for Notch1 Site 2 Cleavage

Geert van Tetering et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Cell Biology

Enhancement of Notch receptor maturation and signaling sensitivity by Cripto-1

Kazuhide Watanabe et al.

JOURNAL OF CELL BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Selective Use of ADAM10 and ADAM17 in Activation of Notch1 Signaling

Esra Cagavi Bozkulak et al.

MOLECULAR AND CELLULAR BIOLOGY (2009)

Article Cardiac & Cardiovascular Systems

Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms

Stephen H. McKellar et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2007)

Article Genetics & Heredity

NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway

Ryan McDaniell et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2006)

Article Multidisciplinary Sciences

Mutations in NOTCH1 cause aortic valve disease

V Garg et al.

NATURE (2005)

Article Cell Biology

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

U Sahin et al.

JOURNAL OF CELL BIOLOGY (2004)

Article Multidisciplinary Sciences

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

AP Weng et al.

SCIENCE (2004)

Article Biochemistry & Molecular Biology

Murine Notch homologs (N1-4) undergo presenilin-dependent proteolysis

MT Saxena et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Biochemistry & Molecular Biology

The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian sel-10 homolog

C Öberg et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Multidisciplinary Sciences

Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members

T Mizutani et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Biochemistry & Molecular Biology

Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors

K Shimizu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)

Article Medicine, Research & Experimental

The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients

A Joutel et al.

JOURNAL OF CLINICAL INVESTIGATION (2000)