Journal
MOLECULAR AND CELLULAR BIOLOGY
Volume 34, Issue 12, Pages 2339-2349Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/MCB.00042-14
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Funding
- NIH [GM068758]
- Ministero della Salute [RF-2010-2306205]
- AICR [10-0527]
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White adipose tissue (WAT) releases fatty acids from stored triacylglycerol for an energy source. Here, we report that targeted deletion of KH-type splicing regulatory protein (KSRP), an RNA-binding protein that regulates gene expression at multiple levels, enhances lipolysis in epididymal WAT (eWAT) because of the upregulation of genes promoting lipolytic activity. Expression of microRNA 145 (miR-145) is decreased because of impaired primary miR-145 processing in Ksrp(-/-) eWAT. We show that miR-145 directly targets and represses Foxo1 and Cgi58, activators of lipolytic activity, and forced expression of miR-145 attenuates lipolysis. This study reveals a novel in vivo function of KSRP in controlling adipose lipolysis through posttranscriptional regulation of miR-145 expression.
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