Journal
MOLECULAR AND CELLULAR BIOLOGY
Volume 32, Issue 24, Pages 4892-4897Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/MCB.01127-12
Keywords
-
Categories
Funding
- NSF [MCB-1050470]
- Government of the Russian Federation [220]
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1440356, 1050470] Funding Source: National Science Foundation
Ask authors/readers for more resources
Enhancers are regulatory DNA sequences that activate transcription over long distances. Recent studies revealed a widespread role of distant activation in eukaryotic gene regulation and in development of various human diseases, including cancer. Genomic and gene-targeted studies of enhancer action revealed novel mechanisms of transcriptional activation over a distance. They include formation of stable, inactive DNA-protein complexes at the enhancer and target promoter before activation, facilitated distant communication by looping of the spacer chromatin-covered DNA, and promoter activation by mechanisms that are different from classic recruiting. These studies suggest the similarity between the looping mechanisms involved in enhancer action on DNA in bacteria and in chromatin of higher organisms.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available