Journal
MOLECULAR AND CELLULAR BIOLOGY
Volume 31, Issue 7, Pages 1565-1576Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/MCB.01122-10
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Funding
- National Institutes of Health [R01-CA65861, P30-DK32520]
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The c-Jun NH2-terminal kinase (JNK) signal transduction pathway causes increased gene expression mediated, in part, by members of the activating transcription factor protein (AP1) group. JNK is therefore implicated in the regulation of cell growth and cancer. To test the role of JNK in Ras-induced tumor formation, we examined the effect of compound ablation of the ubiquitously expressed genes Jnk1 plus Jnk2. We report that JNK is required for Ras-induced transformation of p53-deficient primary cells in vitro. Moreover, JNK is required for lung tumor development caused by mutational activation of the endogenous KRas gene in vivo. Together, these data establish that JNK plays a key role in Ras-induced tumorigenesis.
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