Journal
MOLECULAR AND CELLULAR BIOLOGY
Volume 30, Issue 8, Pages 1937-1945Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/MCB.01370-09
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Funding
- NIH [GM029090, HL050560]
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The ancient MYH7b gene, expressed in striated muscle and brain, encodes a sarcomeric myosin and the intronic microRNA miR-499. We find that skipping of an exon introduces a premature termination codon in the transcript that downregulates MYH7b protein production without affecting microRNA expression. Among other genes, endogenous miR-499 targets the 3' untranslated region of the transcription factor Sox6, which in turn acts as a repressor of MYH7b transcriptional activity. Thus, concerted transcription and alternative splicing uncouple the level of expression of MYH7b and miR-499 when their coexpression is not required.
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