Journal
MOLECULAR AND CELLULAR BIOLOGY
Volume 30, Issue 2, Pages 508-523Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/MCB.00916-08
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Funding
- NIH [CA94184, CA126903, CA42978, CA67771, CA109550]
- Leukemia and Lymphoma Scholar
- Department of Defense Breast Cancer Research
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The small GTPase Ras, which transmits extracellular signals to the cell, and the kinase Aurora-A, which promotes proper mitosis, can both be inappropriately activated in human tumors. Here, we show that Aurora-A in conjunction with oncogenic Ras enhances transformed cell growth. Furthermore, such transformation and in some cases also tumorigenesis depend upon S194 of RalA, a known Aurora-A phosphorylation site. Aurora-A promotes not only RalA activation but also translocation from the plasma membrane and activation of the effector protein RalBP1. Taken together, these data suggest that Aurora-A may converge upon oncogenic Ras signaling through RalA.
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