Journal
MOLECULAR AND CELLULAR BIOCHEMISTRY
Volume 368, Issue 1-2, Pages 127-135Publisher
SPRINGER
DOI: 10.1007/s11010-012-1351-6
Keywords
Mesenchymal stem cells; Schwann cells; Differentiation; Transdifferentiation; Mechanisms; Clinical application
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Funding
- National Natural Science Foundation of China [81000011, 81000835]
- Distinguished Young Talents in Higher Education of Guangdong [LYM091182009]
- Guangdong Natural Science Foundation [10451018201004913]
- Shenzhen Technological RD Foundation [JC201005280429A]
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Schwann cells are critically important in recovery from injuries to the peripheral nervous system, and their absence from the central nervous system (CNS) may be a critical limiting factor in the CNS regeneration capacity. Various types of stem cells have been investigated for their potential to be induced to develop a Schwann cell phenotype, with mesenchymal stem cells (MSCs) being the most promising among them. The methods for inducing MSCs differentiation into Schwann cell-like cells are presented in detail in this review. The evidence related to successful differentiation of MSCs to Schwann cell-like cells is particularly discussed herein, which includes the changes in morphology, phenotype, function, and proteome. The possible explanations for the differentiation of MSCs to Schwann cell-like cells are also presented. Finally, we suggest future research aims which will need to be fulfilled to elucidate the biology of Schwann cell differentiation and MSC transdifferentiation, to enable clinical application of therapeutic differentiated MSC transplantation into nerve injury sites.
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