Journal
MOLECULAR AND CELLULAR BIOCHEMISTRY
Volume 356, Issue 1-2, Pages 209-216Publisher
SPRINGER
DOI: 10.1007/s11010-011-0961-8
Keywords
CK2; Morphogenesis; Embryo development; Proliferation; Apoptosis
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Funding
- NCI NIH HHS [R01 CA71796, R01 CA071796] Funding Source: Medline
- NIEHS NIH HHS [P01 ES011624, P01 ES11624] Funding Source: Medline
- NIGMS NIH HHS [R01 GM098367] Funding Source: Medline
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CK2 is a highly conserved serine-threonine kinase involved in biological processes such as embryonic development, circadian rhythms, inflammation, and cancer. Biochemical experiments have implicated CK2 in the control of several cellular processes and in the regulation of signal transduction pathways. Our laboratory is interested in characterizing the cellular, signaling, and molecular mechanisms regulated by CK2 during early embryonic development. For this purpose, animal models, including mice deficient in CK2 genes, are indispensable tools. Using CK2 alpha gene-deficient mice, we have recently shown that CK2 alpha is a critical regulator of mid-gestational morphogenetic processes, as CK2 alpha deficiency results in defects in heart, brain, pharyngeal arch, tail bud, limb bud, and somite formation. Morphogenetic processes depend upon the precise coordination of essential cellular processes in which CK2 has been implicated, such as proliferation and survival. Here, we summarize the overall phenotype found in CK2 alpha (-/-) mice and describe our initial analysis aimed to identify the cellular processes affected in CK2 alpha mutants.
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