Journal
MOLECULAR AND CELLULAR BIOCHEMISTRY
Volume 347, Issue 1-2, Pages 95-101Publisher
SPRINGER
DOI: 10.1007/s11010-010-0617-0
Keywords
GDNF; RET; High glucose; Pancreatic cancer; Proliferation
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Funding
- National Natural Scientific Foundation on China [30900705]
- Scientific Grant of Xi'an City [GG06718]
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Hyperglycemia promotes pancreatic cancer progression, while the underlying mechanism is uncertain. We investigated the cell proliferation, glial cell line-derived neuotrophic factor (GDNF) and its tyrosine kinase receptor RET expression in BxPC-3 and MIA PaCa-2 cells when exposed to different concentrations of glucose. Proliferation of both cells was effected by glucose in a concentration-dependent manner. Definite expression of GDNF and RET was detected in both cells. Glucose concentrations could alter the expression of GDNF and RET in a concentration-dependent manner, correspondingly with the alterations of cell proliferation. Up-regulation of GDNF and RET ligand-receptor interaction might participate in the glucose-induced cancer progression.
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