Journal
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
Volume 179, Issue 2, Pages 51-58Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molbiopara.2011.06.006
Keywords
Differentiation; Gene regulation; Systems biology; Parasites; Therapeutic; Antigenic variation
Categories
Funding
- Wellcome Trust
- MRC
- BBSRC
- Medical Research Council [G0900255] Funding Source: researchfish
- MRC [G0900255] Funding Source: UKRI
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Most trypanosomatid parasites have both arthropod and mammalian or plant hosts, and the ability to survive and complete a developmental program in each of these very different environments is essential for life cycle progression and hence being a successful pathogen. For African trypanosomes, where the mammalian stage is exclusively extracellular, this presents specific challenges and requires evasion of both the acquired and innate immune systems, together with adaptation to a specific nutritional environment and resistance to mechanical and biochemical stresses. Here we consider the basis for these adaptations, the specific features of the mammalian infective trypanosome that are required to meet these challenges, and how these processes both inform on basic parasite biology and present potential therapeutic targets. (C) 2011 Elsevier B.V. All rights reserved.
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