Journal
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
Volume 166, Issue 2, Pages 93-98Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molbiopara.2009.03.007
Keywords
Malaria; Gametocytes; Transmission-blocking vaccines
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The re-establishment of elimination and eradication on the malaria control agenda has led to calls for renewed effort in the development of parasite transmission-blocking interventions. Vaccines are ideally suited to this task, but progress towards an anti-gamete transmission-blocking vaccine, designed to act on parasites in blood-fed mosquitoes, has been slow. Recent work has confirmed that the surface of the gametocyte-infected erythrocyte presents antigens to the host immune system, and elicits specific humoral immune responses to these antigens, termed gametocyte surface antigens (GSAs). Likely candidate molecules, including antigens encoded by sub-telomeric multi-gene families, are discussed, and a hypothetical group of parasite molecules involved in spatial and temporal signal transduction in the human host is proposed, the tropins and circadins. The next steps for development of anti-gametocyte transmission-blocking vaccines for P. falciparum and the other human malaria species are considered. (C) 2009 Elsevier B.V. All rights reserved.
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