Journal
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
Volume 167, Issue 1, Pages 48-53Publisher
ELSEVIER
DOI: 10.1016/j.molbiopara.2009.04.006
Keywords
Aquaglyceroporin; Aquaporin 3; Parasitophorous vacuolar membrane; Plasmodium falciparum
Categories
Funding
- Deutsche Forschungsgemeinschaft [SFB593]
- FAZIT foundation
- DFG Graduiertenkolleg [1216]
Ask authors/readers for more resources
The molecular mechanisms underlying the formation of the parasitophorous vacuolar membrane in Plasmodium falciparum infected erythrocytes are incompletely understood, and the protein composition of this membrane is still enigmatic. Although the differentiated mammalian erythrocyte lacks the machinery required for endocytosis, some reports have described a localisation of host cell membrane proteins at the parasitophorous vacuolar membrane. Aquaporin 3 is an abundant plasma membrane protein of various cells, including mammalian erythrocytes where it is found in distinct oligomeric states. Here we show that human aquaporin 3 is internalized into infected erythrocytes, presumably during or soon after invasion. it is integrated into the PVM where it is organized in novel oligomeric states which are not found in non-infected cells. (C) 2009 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available