Journal
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
Volume 157, Issue 2, Pages 127-136Publisher
ELSEVIER
DOI: 10.1016/j.molbiopara.2007.11.005
Keywords
haemozoin; beta-haematin; malaria; schistosoma mansoni; screening; lipid bodies
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Formation of malaria pigment or haemozoin is the major route of haem detoxification in the malaria parasite Plasmodium falciparum as well as several other species of haematophagous organisms, including other Plasmodium species, helminth worms such as Schistosoma mansoni and blood-sucking insects such as Rhodnius prolixus. Recent advances in our understanding of the formation of haemozoin, both from new observations that it is formed within lipid bodies in P. falciparum and S. mansoni and biomimetic studies on the formation of its synthetic counterpart beta-haematin are reviewed. The review also covers methods available for screening compounds for their ability to inhibit P-haematin formation. (c) 2007 Elsevier B.V. All rights reserved.
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