Journal
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
Volume 157, Issue 1, Pages 92-97Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molbiopara.2007.08.010
Keywords
nuclear receptor; filariasis; nematode; E75; Rev-erb alpha
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Filarial parasites cause debilitating diseases in humans and domesticated animals. Brugia malayi and Dirofilaria immitis are transmitted by mosquitoes and infect humans and dogs, respectively. Their life cycle is punctuated by a series of cuticular molts as they move between different hosts and tissues. An understanding of the genetic basis for these developmental transitions may suggest potential targets for vaccines or chemotherapeutics. Nuclear receptor (NR) proteins have been implicated in molting in the free-living nematode Caenorhabditis elegans and have well characterized roles in molting during larval development of Drosophila melanogaster. For example, the D. melanogaster E75 (NR1D3) NR gene is required for molting and metamorphosis, as well as egg chamber development in adult females. We have identified Bm-nhr-11 and Di-nhr-6, B. malayi and D. immitis orthologues of E75. Both genes encode canonical nuclear receptor proteins, are developmentally regulated, and are expressed in a sex-specific manner in adults. (c) 2007 Elsevier B.V. All rights reserved.
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