4.1 Article

The canine hookworm genome:: Analysis and classification of Ancylostoma caninum survey sequences

Journal

MOLECULAR AND BIOCHEMICAL PARASITOLOGY
Volume 157, Issue 2, Pages 187-192

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/j.molbiopara.2007.11.001

Keywords

hookworm; Ancylostoma caninum; genome survey sequences; expressed sequence tags; genome; comparative genomics

Funding

  1. NIAID NIH HHS [U01 AI046593, AI 46593, U01 AI046593-03] Funding Source: Medline

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Hookworms infect nearly a billion people. The Ancylostoma caninum hookworm of canids is a model for studying human infections and information from its genome coupled with functional genomics and proteomics can accelerate progress towards hookworm control. As a step towards a full-scale A. caninum genome project, we generated 104,000 genome survey sequences (GSSs) and determined the genome size of the canine hookworm. GSSs assembled into 57.6 Mb of unique sequence from a genome that we estimate by flow cytometry of isolated nuclei to be 347 +/- 1.2 Mb, substantially larger than other Rhabditina species. Gene finding identified 5538 genes in the GSS assembly, for a total of 9113 non-redundant A. caninum genes when EST sequences are also considered. Functional classifications of many of the 70% of genes with homology to genes in other species are provided based on gene ontology and KEGG associations and secreted and membrane-bound proteins are also identified. (c) 2007 Elsevier B.V. All rights reserved.

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