Journal
MOLECULAR & CELLULAR PROTEOMICS
Volume 12, Issue 4, Pages 846-855Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/mcp.R112.026799
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Funding
- National Institutes of Health
- Department of Defense
- Tobacco Related Disease Research Program
- LUNGevity Foundation
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Changes in glycosylation readily occur in cancer and other disease states. Thanks to recent advances in the development of analytical techniques and instrumentation, especially in mass spectrometry, it is now possible to identify blood-derived glycan-based biomarkers using glycomics strategies. This review is an overview of the developments made in the search for glycan-based cancer biomarkers and the technologies currently in use. It is anticipated that the progressing instrumental and bioinformatics developments will allow the identification of relevant glycan biomarkers for the diagnosis, early detection, and monitoring of cancer treatment with sufficient sensitivity and specificity for clinical use. Molecular & Cellular Proteomics 12: 10.1074/mcp.R112.026799, 846-855, 2013.
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