Journal
MODERN RHEUMATOLOGY
Volume 25, Issue 2, Pages 215-218Publisher
SPRINGER
DOI: 10.3109/14397595.2014.942503
Keywords
Antiphospholpid syndrome; Lupus anticoagulant; Phosphatidylserine-dependent anti-prothrombin antibody; Pregnancy
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Funding
- Grants-in-Aid for Scientific Research [25670455, 25461466, 26293230] Funding Source: KAKEN
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Objective. To clarify the clinical significance of antiphospholipid antibody (aPL) profile in patients with obstetric antiphospholipid syndrome (APS). Methods. Clinical records of 13 pregnant patients (15 pregnancies) with obstetrical APS were reviewed over 10 years. Patients who met the Sapporo Criteria fully were studied, whereas those with only early pregnancy loss were excluded. In addition to classical aPL: lupus anticoagulant (LA), anticardiolipin antibody (aCL), and anti-beta(2)-glycoprotein I (a beta 2GPI); phosphatidylserine-dependent anti-prothrombin antibody (aPS/PT) and kininogen-dependent anti-phosphatidylethanolamine antibody (aPE) were also examined in each case. Results. Cases were divided into two groups according to patient response to standard treatment: good and poor outcome groups. All cases with poor outcome presented LA, with IgG a beta 2GPI and IgG aPS/PT were also frequently observed. IgG aPE did not correlate with pregnancy outcome. Conclusion. aPL profile may predict pregnancy outcome in patients with this subset of obstetric APS.
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