Journal
MODERN PATHOLOGY
Volume 27, Issue 10, Pages 1310-1320Publisher
ELSEVIER SCIENCE INC
DOI: 10.1038/modpathol.2014.33
Keywords
colorectal cancer; diagnosis; dysregulation; long non-coding RNA; prognosis
Categories
Funding
- National Clinical Key Discipline
- Clinical Key Discipline Fund by Ministry of Health
- Academic Award for Doctoral Candidates by Ministry of Education
- Mingdao Fund for Medical Graduate Student by Shanghai Medical College
- Shanghai Science and Technology Development Fund (Basic Research Major Project) [10DJ1400500]
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Long non-coding RNAs (IncRNAs) are a class of newly identified non-coding RNA molecules that are emerging as key regulators of tumor initiation and development. Colorectal cancer (CRC) remains a major health problem worldwide, and there remains a need to further refine the current screening approaches as well as provide tailored diagnostic and therapeutic approaches. Multiple dysregulated IncRNAs participate in tumorigenesis through a variety of molecular mechanisms, and various regulatory factors frequently contribute to the aberrant expression of IncRNAs in CRC, thereby allowing malignant transformation. Additionally, the association of dysregulated IncRNAs with specific developmental stages and clinical outcomes indicates their potential as strong diagnostic and prognostic predictors as well as therapeutic targets. Here we provide a brief overview of the known functions of CRC-associated IncRNAs, describe some potential molecular mechanisms that underlie changes in IncRNA expression in CRC, and attempt to uncover their clinical and therapeutic potential.
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