Journal
MODERN PATHOLOGY
Volume 24, Issue 2, Pages 157-167Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/modpathol.2010.200
Keywords
basal-like; breast cancer; definition; practical review; triple-negative
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Breast cancer is a heterogeneous disease encompassing a variety of entities with distinct morphological features and clinical behaviors. Although morphology is often associated with the pattern of molecular aberrations in breast cancers, it is also clear that tumors of the same histological type show remarkably different clinical behavior. This is particularly true for 'basal-like cancer', which is an entity defined using gene expression analysis. The purpose of this article was to review the current state of knowledge of basal-like breast cancers, to discuss the relationship between basal-like and triple-negative breast cancers, and to clarify practical implications of these diagnoses for pathologists and oncologists. Modern Pathology (2011) 24, 157-167; doi:10.1038/modpathol.2010.200; published online 12 November 2010
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